Publications

2024

Long-term safety and efficacy of transcatheter microwave and radiofrequency denervation in chronic ovine model JAHA 2024

Contributors from ADDRI: Dr Virginia James PhD

Reference:

Qian. P, Barry. M. Balaji.P, V.tran, S.Marscher, Mina.A, S. Banodkar, S.Alvarez, V. James, J.Ronquillo, W. Varikatt, P. Kovoor, A.McEwan, and S.Thomas. Long-term safety and efficacy of transcatheter microwave and radiofrequency denervation in chronic ovine model JAHA 2024- in publication.

Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. Welsh JA, Goberdhan DCI, Lorraine O'Driscoll, MISEV consortium, Witwer KW. JEV, 2024 (IF: 17.37)

Real world efficacy and toxicity of consolidation durvalumab following chemoradiotherapy in older Australian patients with unresectable stage III non-small cell lung cancer

Contributors from ADDRI: Dr Anthony Linton

Reference:

Stevens S, Nindra U, Shahnam A, Wei J, Bray V, Pal Abhijit, Yip PY, Linton A, et al. Real world efficacy and toxicity of consolidation durvalumab following chemoradiotherapy in older Australian patients with unresectable stage III non-small cell lung cancer. Journal of Geriatric Oncology. 2024. 15 101705

2023

Expression Regulates Burn Wound Healing and Can Be Targeted to Modify Scar Characteristics.

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Tsai K, Shi H, Naficy S, Wang XS et al. Skin 11β-HSD1 Expression Regulates Burn Wound Healing and Can Be Targeted to Modify Scar Characteristics. Burns and Trauma 11

Advanced pathophysiology mimicking lung models for accelerated drug discovery.

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Phan TH, Shi H, Denes CE, Cole AJ, Wang Y, Cheng YY, Neely GG, Chang JH, Chrzanowski W. Advanced pathophysiology mimicking lung models for accelerated drug discovery. Biomaterial Research 27(1):35

Leptospermum extract (QV0) suppresses malignant mesothelioma tumour growth in vitro and in vivo.

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Shi H, Yu TK, Zheng L, Ke H, Vuong Q, Rath E, Lee K, Kao S, Cheng YY. Leptospermum extract (QV0) suppresses malignant mesothelioma tumour growth in vitro and in vivo. Frontiers in Oncology 13:1162027

A structural analysis of the nsp9 protein from the coronavirus MERS CoV reveals a conserved RNA binding interface

Contributors from ADDRI: David Baker

Reference:

A structural analysis of the nsp9 protein from the coronavirus MERS CoV reveals a conserved RNA binding interface https://doi.org/10.1002/prot.26630

Immuno Inertial microfluidics: a novel strategy for exosome subpopulation separation.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Razavi Bazaz S, Zhand S, Salomon R, Ortega DG, Hosseini-Beheshti E, Jin D, Warkiani M. Immuno Inertial microfluidics: a novel strategy for exosome subpopulation separation. Micromachines 2023, 14, 751. (IF:3.52)

Small and large extracellular vesicles derived from pleural mesothelioma cell lines offer biomarker potential Cancers

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Ahmadzada T, Vijayan A, Vafaee F, Reid G, Kao S, Grau GER, Clark S, Hosseini-Beheshti E. Small and large extracellular vesicles derived from pleural mesothelioma cell lines offer biomarker potential Cancers (Basel). 2023 Apr 18;15(8):2364. (IF:6.57)

Immunomodulatory Potential of Human Clonal Mesenchymal Stem Cells and 2 their Extracellular Vesicle Subpopulations in an Inflammatory-Mediated 3 Diabetic Rhesus Monkey Model, accepted in Life Sciences.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Assar Kashani S, Navabi R, Amini A, Hajinasrollah M, Jenab Y , Rabbani Sh, Nazari A, Pakzad M, Moazenchi M, Jafari Atrabi M, Samsonchi Z, Hezavehei M, Hosseini-Beheshti E, Shekari F, Hajizadeh-Saffar E, Baharvand H. Immunomodulatory Potential of Human Clonal Mesenchymal Stem Cells and 2 their Extracellular Vesicle Subpopulations in an Inflammatory-Mediated 3 Diabetic Rhesus Monkey Model, accepted in Life Sciences. (IF: 6.78)

A novel dye-sensitised solar cell based portable sensor for chemical detection, Accepted in Sensors and Actuators B: Chemical

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Xue Y, Lei B, Feng X, Ye M, Hazelton P, Huang Y, Fan X, Zhu G, Robertson N, Hosseini-Beheshti E, Chen X. A novel dye-sensitised solar cell based portable sensor for chemical detection, Accepted in Sensors and Actuators B: Chemical (IF: 8.4)

Engineered extracellular vesicles expressing ICAM-1: A promising targeted delivery system for T cell modifications

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Shahrabi Farahani M, Hosseini-Beheshti E, Moazzeni SM, Forouzandeh Moghadam M. Engineered extracellular vesicles expressing ICAM-1: A promising targeted delivery system for T cell modifications. Biochim Biophys Acta Gen Subj. 2023 Dec 14:130541. doi: 10.1016/j.bbagen.2023.130541. Online ahead of print

Lidocaine for Neuropathic Cancer Pain (LiCPain): study protocol for a mixed methods pilot study

Contributors from ADDRI: Dr Anthony Linton

Reference:

Lee J, Currow D, Phillips JL, McLachlan A, Linton A, et al. Lidocaine for Neuropathic Cancer Pain (LiCPain): study protocol for a mixed methods pilot study. BMJ Open. 2023 Feb 21;13(2):e066125.

High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma.

Contributors from ADDRI: Dr Anthony Linton

Reference:

Chu GJ, Linton A, Kao SC, Klebe S, et al. High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma. Histopathology. 2023. Accepted for publication.

2022

Exploring MicroRNA and exosome involvement in malignant pleural mesothelioma drug response.

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Johnson B, Zhuang L, Rath E, Yuen ML, Cheng NC, Shi H, Kao S, Reid G, Cheng YY. Exploring MicroRNA and exosome involvement in malignant pleural mesothelioma drug response. Cancers (Basel) 14(19):4784

Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone (PCL) electrospun scaffold accelerates burn wound healing.

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Shi H, Tsai K, Ma D, Wang X, Desai R, Parungao RJ, Hunt NJ, Cheng Y, Zhang H, Xu Y, Simanainen U, Tan Q, Cooper MS, Handelsman DJ, Maitz PK, Wang Y. Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone (PCL) electrospun scaffold accelerates burn wound healing. The FASEB Journal 36 (5) e22310

3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumour microenvironment for drug response studies.

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Shi H, Rath E, Sarun KH, Lin R, Clarke CJ, McCaughan B, Ke H, Linton A, Lee K, Klebe S, Maitz J, Song K, Wang Y, Kao S, Cheng Y. 3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumour microenvironment for drug response studies. Frontiers in Oncology, p4258

Exploring the role of extracellular vesicles and their protein cargo in lung cancer metastasis: a review

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Whittle K, Kao S, Clarke S, Grau GER, Hosseini-Beheshti E. Exploring the role of extracellular vesicles and their protein cargo in lung cancer metastasis: a review. Crit Rev Oncol Hematol 2022 Jan 20;103603. (IF: 6.31)

Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Xu J, Yang KC, Colborne S, Hosseini-Beheshti E, Guns E, Morin G, Gorski SM. Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations. Autophagy. 2022 Feb 7. IF: 16.02

Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Al Halawani, A.; Mithieux, S.M.; Yeo, G.C.; Hosseini-Beheshti, E.; Weiss, A.S. Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses. Int. J. Mol. Sci. 2022, 23, 3389. (IF: 5.92)

Extracellular vesicles from biological fluids as potential markers in castration resistant prostate cancer.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Choi W, Sánchez C, Li JJ, Dinarvand M, Adomat H, Ghaffari M, Khoja L, Vafaee F, Joshua A, Chi KN, Tomlinson Guns ES, Hosseini-Beheshti E. Extracellular vesicles from biological fluids as potential markers in castration resistant prostate cancer. J Cancer Res Clin Oncol. 2022 Oct 12. (IF: 4.55).

Bacterial extracellular vesicles and their novel applications in health.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini Giv N, Bass A, Hicks C, El-Omar E, El-Assad F, Hosseini-Beheshti E. Bacterial extracellular vesicles and their novel applications in health. Front Cell Infect Microbiol. 2022 Nov 11;12:962216. (IF: 5.3).

Lipidomics profiles of plasma microvesicles differ in experimental cerebral malaria, compared to malaria without neurological complications.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Batarseh A, Vafaee F, Hosseini-Beheshti E, Chen A, Cohen A, Juillard A, Hunt NH, Mariani M, Mitchel T and Grau GER. Lipidomics profiles of plasma microvesicles differ in experimental cerebral malaria, compared to malaria without neurological complications. Int J Mol Sci. 2022 Dec 28;24(1):501. (IF:6.21)

GUIDE: a randomised non-comparative phase II trial of biomarker-driven intermittent docetaxel versus standard-of-care docetaxel in metastatic castration-resistant prostate cancer (clinical trial protocol)

Contributors from ADDRI: Dr Anthony Linton

Reference:

Conduit C, Mak B ,Lulio JD, Burder R, Linton A, et al. GUIDE: a randomised non-comparative phase II trial of biomarker-driven intermittent docetaxel versus standard-of-care docetaxel in metastatic castration-resistant prostate cancer (clinical trial protocol). Ther Adv Med Oncol 2022. Apr 18:14.

The Minimum Standard of Care for Managing Malignant Pleural Mesothelioma in Developing Nations within the Asia-Pacific Region.

Contributors from ADDRI: Dr Anthony Linton

Reference:

Ke H, Kao S, Lee K, Takahashi K, Goh H, Linton A. The Minimum Standard of Care for Managing Malignant Pleural Mesothelioma in Developing Nations within the Asia-Pacific Region. Asia Pac J Clin Oncol. 2022. June;18(3): 177-190

3-Dimensional mesothelioma spheroids provide closer to natural pathphysiological tumour microenvironment for drug response studies.

Contributors from ADDRI: Dr Anthony Linton

Reference:

Huaikai S, Rath E, Sarun K, Lin R, Linton A, et al. 3-Dimensional mesothelioma spheroids provide closer to natural pathphysiological tumour microenvironment for drug response studies. Frontiers in Oncology. 2022. Aug 26;12:973576

2021

The contradictory role of androgens in cutaneous and major burn wound healing.

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Shi H, Cheer K, Simanainen U, Lesmana B, Ma D, Hew JJ, Parungao RJ, Li Z, Cooper M, Handelsman DJ, Maitz P, Wang Y. The contradictory role of androgens in cutaneous and major burn wound healing. Burns and Trauma vol.9

Extracellular vesicles as biomarkers in Malignant Pleural Mesothelioma: A review.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Ahmadzada T, Kao S, Reid G, Clarke S, Grau GE, Hosseini-Beheshti E. Extracellular vesicles as biomarkers in Malignant Pleural Mesothelioma: A review. Critical Reviews in Oncology/Hematology. 2020;150:102949. (IF: 6.31)

Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Ryan ST, Hosseini-Beheshti E, Afrose D, Ding X, Xia B, Grau GE, Little CB, McClements L, Li JJ. Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions. Int J Mol Sci. 2021 Mar 16;22(6):3023.doi: 10.3390/ijms22063023. (IF: 5.92)

Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: implications for clinical practice.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Oey O, Ghaffar M, Li J, Hosseini-Beheshti E. Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: implications for clinical practice. Crit Rev Oncol Hematol 2021 Oct 13;103495. (IF: 6.31)

Evaluation of a Mainstream Model of Genetic Testing for Men with Prostate Cancer

Contributors from ADDRI: Dr Anthony Linton

Reference:

Scheinberg T, Goodwin A, Ip E, Linton A, et al. Evaluation of a Mainstream Model of Genetic Testing for Men with Prostate Cancer. JCO Oncol Pract. 2021 Feb:17(2):e204-e216)

The Role of E-Cadherin and microRNA on FAK Inhibitor Response in Malignant Pleural Mesothelioma (MPM)

Contributors from ADDRI: Dr Anthony Linton

Reference:

Yuen ML, Zhunag L, Rath EM, Yu T, Linton A, et al. The Role of E-Cadherin and microRNA on FAK Inhibitor Response in Malignant Pleural Mesothelioma (MPM). Int J Mol Sci. 2021 Sep 23:22(19):10225

2020

Retrospective evaluation of the use of pembrolizumab in malignant pleural mesothelioma.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Ahmadzada T, Cooper W, Holmes M, Westman H, Gill1 A, Nordman I, Yip PY, Pal A, Zielinski R, Pavlakis N, Nagrial A, Brungs D, Karikos D, Aleksova V, Burns J, Asher R, Grau GE , Hosseini-Beheshti E, Reid G, Clarke S, Kao S. Retrospective evaluation of the use of pembrolizumab in malignant pleural mesothelioma. JTOCRR 100075. (IF=15.61)

The Current Understanding of Asbestos-Induced Epigenetic Changes Associated with Lung Cancer. Lung Cancer

Contributors from ADDRI: Dr Anthony Linton

Reference:

Cheng YY, Rath EM, Linton A, et al. The Current Understanding of Asbestos-Induced Epigenetic Changes Associated with Lung Cancer. Lung Cancer. 2020 Jan 8;11:1-11. doi: 10.2147/LCTT.S186843. eCollection 2020.

A Potential Alternative Method in Diagnosis Compared to Fluorescnece In Situ Hybridisation

Contributors from ADDRI: Dr Anthony Linton

Reference:

Cheng YY, Yuen ML, Rath EM, Linton A, et al. CDKN2A and MTAP Are Useful Biomarkers Detectable by Droplet Digital PCR in Malignant Pleural Mesothelioma: A Potential Alternative Method in Diagnosis Compared to Fluorescnece In Situ Hybridisation. Front Oncol. 2020. Nov 13;10:579327

2019

Transvascular Pacing of aorticorenal ganglia provides testable procedural endpoint for renal artery denervation.

Contributors from ADDRI: Dr Virginia James PhD

Reference:

Qian. P, Barry. M. Lu, Pouliopoulos, J, Mina. A, Bandodkar. S, James. V, Ronquillo. J. Thomas, S. et al. ▪ Transvascular Pacing of aorticorenal ganglia provides testable procedural endpoint for renal artery denervation. JACC: Cardiovascular Interventions 2019.

Extracellular vesicles and microvascular pathology: Decoding the active dialogue.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Grau GER. Extracellular vesicles and microvascular pathology: Decoding the active dialogue. Microcirculation. 2019;26:e12485. (IF=2.63)

Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Balaban S, Nassar ZD, Zhang AY, Hosseini-Beheshti E, Centenera MM, Schreuder M, Lin HM, Aishah A, Varney B, Liu-Fu F, Lee LS, Nagarajan SR, Shearer RF, Hardie RA, Raftopulos NL, Kakani MS, Saunders DN, Holst J, Horvath LG, Butler LM, Hoy AJ. Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer. Mol Cancer Res. 2019 Jan 15. (IF=5.85)

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Li JJ, Hosseini-Beheshti E, Grau GE, Zreiqat H, Little CB. Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis. Nanomaterials (Basel). 2019 Feb 14;9(2). pii: E261. (IF=5.08)

Host- and microbiota-derived extracellular vesicles, immune function and disease development.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Macia L, Nanan R, Hosseini-Beheshti E, Grau GE. Host- and microbiota-derived extracellular vesicles, immune function and disease development. Int. J. Mol. Sci. 2020, 21(1), 107. IF: 5.92

High BIN1 expression has a favourable prognosis in malignant pleural mesothelioma and is associated with tumor infiltrating lymphocytes

Contributors from ADDRI: Dr Anthony Linton

Reference:

Ahmadzada T, Lee K, Clarke C, Cooper WA, Linton A, et al. High BIN1 expression has a favourable prognosis in malignant pleural mesothelioma and is associated with tumor infiltrating lymphocytes. Lung Cancer. 2019 Apr; 130:35-41.

Patterns of care and survival of older patients with malignant pleural mesothelioma

Contributors from ADDRI: Dr Anthony Linton

Reference:

Linton A, Blinman P, Kao S, van Zandwijk N. Patterns of care and survival of older patients with malignant pleural mesothelioma. Jour Geriatric Oncology. 2019 July; 10(4):573-576.

2018

Transcatheter microwave ablation can deliver deep and circumferential perivascular nerve injury without significant arterial injury to provide effective renal denervation.

Contributors from ADDRI: Dr Virginia James PhD

Reference:

Qian. P, Barry. M. Lu, Al Raisi. S, Mina. A, Ryan. J, Bandodkar. S, James. V, Chong. J, Thomas, S. et al. ▪ Transcatheter microwave ablation can deliver deep and circumferential perivascular nerve injury without significant arterial injury to provide effective renal denervation. Journal of Hypertension 2018.

Extracellular vesicles as mediators of immunopathology in infectious diseases.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Grau G. Extracellular vesicles as mediators of immunopathology in infectious diseases. Immunol Cell Biol. 2018 Mar 25. (IF=5.13)

Interplay of Extracellular Vesicles and Other Players in Cerebral Malaria Pathogenesis.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Debs S, Cohen A, Hosseini-Beheshti E, Chimini G, Hunt NH, and Grau G. Interplay of Extracellular Vesicles and Other Players in Cerebral Malaria Pathogenesis. Biochim Biophys Acta Gen Subj. 2018 Oct 17;1863(2):325-331. (IF=3.77)

Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma

Contributors from ADDRI: Dr Anthony Linton

Reference:

Johnson TG, Schelch K, Cheng YY, Williams M, Sarun KH, Kirschner MB, Kao S, Linton A, et al. Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma. J Thorac Oncol. 2018 Feb;13(2):258- 272. doi: 10.1016/j.jtho.2017.10.016. Epub 2017 Nov 4.

2017

Role of hepatic Annexin A6 in fatty acid -induced lipid droplet formation.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Cairns R, Alvarez-Guaita A, Martínez-Saludes I, Wason SJ, Hhan J, Nagarajan SR, Hosseini-Beheshti E, Monastyrskaya K, Hoy AJ, Buechler C, Enrich C, Rentero C, Role of hepatic Annexin A6 in fatty acid -induced lipid droplet formation. Exp Cell Res. 2017 Jul 14. pii: S0014-4827(17)30368-3. (IF=3.91)

Geographic and socioeconomic factors in patients with malignant pleural mesothelioma in New South Wales and their impact upon clinical outcomes

Contributors from ADDRI: Dr Anthony Linton

Reference:

Linton A, Soeberg M, Broome R, Kao S, van Zandwijk N. Geographic and socioeconomic factors in patients with malignant pleural mesothelioma in New South Wales and their impact upon clinical outcomes. Respirology. 2017 July; 22(5): 978-985

Tumour suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma

Contributors from ADDRI: Dr Anthony Linton

Reference:

Kao SC, Cheng YY, Williams M, Kirschner MB, Linton A, et al. Tumour suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma. Journal Thoracic Oncology. 2017 Jun 16. pii: S1556-0864(17)30460-4.

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study. Lancet Oncology

Contributors from ADDRI: Dr Anthony Linton

Reference:

van Zandwijk N, Pavlakis N, Kao SC, Linton A, et al. Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study. Lancet Oncology. 2017 Oct;18(10):1386-1396. doi: 10.1016/S1470-2045(17)30621-6. Epub 2017 Sep 1

2016

Exosomes Confer Pro-survival Signals to Alter the Phenotype of Prostate Cells in Their Surrounding Environment.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Choi W, Weiswald LB, Kharmate G, Ghaffari M, Roshan-Moniri M, Hassona MD, Chan L, Chin MY, Rennie PS, Tai IT, Fazli L, Guns (Tomlinson) ES. Exosomes Confer Pro-survival Signals to Alter the Phenotype of Prostate Cells in Their Surrounding Environment. Oncotarget. 2016 Mar 22;7(12):14639-58. (IF=5.20)

Epidermal Growth Factor in Prostate Cancer derived Exosomes.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Kharmate G, Hosseini-Beheshti E, Caradec J, Chin MY Guns (Tomlinson) ES. Epidermal Growth Factor in Prostate Cancer derived Exosomes. PLoS One. 2016 May 6;11(5):e0154967. (IF=3.24)

2015

LB1.5 Initial interactions of herpes simplex virus with human skin dendritic cells.

Contributors from ADDRI: Dr Virginia James PhD

Reference:

Min. K, Truong N. R, V. James, Cunningham. A. LB1.5 Initial interactions of herpes simplex virus with human skin dendritic cells. Sexually Transmitted Infections (BMJ) 2015

Large Oncosomes Contain Distinct Protein Cargo and Represent a Separate Functional Class of Tumor-Derived Extracellular Vesicles.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Minciacchi V, You S, Spinelli C, Morley S, Zandian M, Aspuria PJ, Cavallini L, Ciardiello C, Sobreiro MR, Morello M, Kharmate G, Jang S, Kim DK, Hosseini-Beheshti E, Guns E, Gleave M, Gho Y, Mathivanan S, Yang W, Freeman M, Di Vizio D. Large Oncosomes Contain Distinct Protein Cargo and Represent a Separate Functional Class of Tumor-Derived Extracellular Vesicles. Oncotarget. 2015 May 10;6(13):11327-41. (IF=5.01)

MiR-score: a novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma

Contributors from ADDRI: Dr Anthony Linton

Reference:

Kirschner MB, Cheng YY, Armstrong NJ, Lin RC, Kao SC, Linton A, Klebe S, McCaughan BC, van Zandwijk N, Reid G. MiR-score: a novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma. Molecular Oncology. 2015; 9(3): 715-26.

miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma.

Contributors from ADDRI: Dr Anthony Linton

Reference:

Williams M, Kirschner MB, Cheng YY, Hanh J, Weiss J, Mugridge N, Wright CM, Linton A, Kao SC, Edelman JJ, Vallely MP, McCaughan BC, Cooper W, Klebe S, Lin RC, Brahmbhatt H, MacDiarmid J, van Zandwijk N, Reid G. miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma. Oncotarget. 2015; 6(27): 23480-95.

2014

Pomegranate Extracts Impact the Androgen Biosynthesis Pathway in Prostate Cancer Models in vitro and in vivo.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Ming DS, Pham S, Adomat H, Deb S, Hosseini-Beheshti E, Chin MY, Locke J, Guns(Tomlinson) ES. Pomegranate Extracts Impact the Androgen Biosynthesis Pathway in Prostate Cancer Models in vitro and in vivo. J Steroid Biochem Mol Biol. 2014 Feb 22;143C:19-28. (IF=4.29)

Reproducibility and efficiency of serum-derived exosome extraction methods.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Caradec J, Kharmate G, Hosseini-Beheshti E, Guns (Tomlinson) ES. Reproducibility and efficiency of serum-derived exosome extraction methods. Clin Biochem. 2014 Sep;47(13-14):1286-92. (IF=3.28)

Next-Generation Steroidogenesis Inhibitors, Dutasteride and Abiraterone, Attenuate but Still Do Not Eliminate Androgen Biosynthesis in 22RV1 Cells in vitro.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Pham S, Deb S, Ming DS, Adomat H, Hosseini-Beheshti E, Zoubeidi A, Gleave M, Tomlinson Guns ES. Next-Generation Steroidogenesis Inhibitors, Dutasteride and Abiraterone, Attenuate but Still Do Not Eliminate Androgen Biosynthesis in 22RV1 Cells in vitro. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:436-44. (IF=4.29)

Regulation of Local Steroidogenesis in the Brain and in Prostate Cancer: Lessons learned from interdisciplinary collaboration.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Fokidis HB, Adomat H, Kharmate G, Hosseini-Beheshti E, Guns E., Soma KK. Regulation of Local Steroidogenesis in the Brain and in Prostate Cancer: Lessons learned from interdisciplinary collaboration. Front Neuroendocrinol. 2014 Sep 16. pii: S0091-3022(14)00077-6. (IF=8.61)

An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma

Contributors from ADDRI: Dr Anthony Linton

Reference:

Linton A, Cheng YY, Griggs K, Kirschner M, Gattani S, Srikaran S, Kao SC, McCaughan B, Klebe S, van Zandwijk N, and Reid G. An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma. British Journal of Cancer. 2014 Jan 21;110(2):510-9.

Factors associated with survival in a large series of patients with malignant pleural mesothelioma in New South Wales

Contributors from ADDRI: Dr Anthony Linton

Reference:

Linton A, Pavlakis N, Kao SC, Clarke S, Vardy J, van Zandwijk N. Factors associated with survival in a large series of patients with malignant pleural mesothelioma in New South Wales. British Journal of Cancer 2014 ; 111(9): 1860-9.

2013

Differing association of macrophage subsets with atherosclerotic plaque stability.

Contributors from ADDRI: Dr Virginia James PhD

Reference:

H.J. Medbury, V. James, J. Ngo, K. Hitos, Y. Wang, D.C Harris, J.P Fletcher. ▪ Differing association of macrophage subsets with atherosclerotic plaque stability. International Angiology 2013.

Immunohistochemistry in the diagnosis of malignant pleural mesothelioma: Trends in Australia and a literature review

Contributors from ADDRI: Dr Anthony Linton

Reference:

Linton A, Kao S, Vardy J, Clarke S, van Zandwijk N, Klebe S. Immunohistochemistry in the diagnosis of malignant pleural mesothelioma: Trends in Australia and a literature review. Asia Pac J Clin Oncol. 2013 Sep;9(3):273-9.

Glasgow Prognostic Score As a Prognostic Factor in Metastatic Castration-Resistant Prostate Cancer Treated With Docetaxel- Based Chemotherapy

Contributors from ADDRI: Dr Anthony Linton

Reference:

Linton A, Pond G, Clarke S, Vardy J, Galsky M, Sonpavde G. Glasgow Prognostic Score As a Prognostic Factor in Metastatic Castration-Resistant Prostate Cancer Treated With Docetaxel- Based Chemotherapy. Clin Genitourin Cancer. 2013 Dec;11(4):423-30

2012

Characterization of Antioxidant Capacity from Fruits with Distinct Anthocyanin Biosynthetic Pathways.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Lund ST. and Kitts DD. Characterization of Antioxidant Capacity from Fruits with Distinct Anthocyanin Biosynthetic Pathways. J Nutr and Food Sci. 2012, 2:122. (IF=3.48)

Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Pham S., Adomat H., Li N, Guns (Tomlinson) ES. Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes. Mol Cell Proteomics. 2012 Oct;11(10):863-85. ** (IF=7.25)

The ticking time-bomb of asbestos: Its insidious role in the development of malignant mesothelioma

Contributors from ADDRI: Dr Anthony Linton

Reference:

Linton A, Vardy J, Clarke S, van Zandwijk N. The ticking time-bomb of asbestos: Its insidious role in the development of malignant mesothelioma. Critical Reviews in Oncology/Hematology. 2012: 84 (2): 200-212.

Inflammation in malignant mesothelioma friend or foe?

Contributors from ADDRI: Dr Anthony Linton

Reference:

Linton A, van Zandwijk N, Reid G, Clarke S, Kao S. Inflammation in malignant mesothelioma friend or foe? Ann Cardiothorac Surg 2012: 1(4):516-522.

Radical surgery for malignant pleural mesothelioma: have we identified the appropriate selection tools?

Contributors from ADDRI: Dr Anthony Linton

Reference:

van Zandwijk N, Reid G, Linton A, Kao S. Radical surgery for malignant pleural mesothelioma: have we identified the appropriate selection tools? Ann Cardiothorac Surg. 2012 Nov;1(4):481-6.

2009

Comparison of Antioxidant Activity of Two Soft Fruits Sources with Different Anthocyanin Composition.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Lund, ST. and Kitts, DD. 2009. Comparison of Antioxidant Activity of Two Soft Fruits Sources with Different Anthocyanin Composition. Acta Hort. 2009. (ISHS) 841:519-522.

Testicular Cancer

Contributors from ADDRI: Dr Anthony Linton

Reference:

Linton A, Grimison P. Testicular Cancer. Australian Doctor: How to Treat. 2009. 17 June. 33-40

2008

Acute Dexamethasone-induced Increase in Cardiac Lipoprotein Lipase Requires Activation of Both Akt and Stress Kinases.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Kewalramani G, Puthanveetil P, Kim MS, Wang F, Lee V, Hau N, Beheshti E, Ng N, Abrahani A, Rodrigues B. Acute Dexamethasone-induced Increase in Cardiac Lipoprotein Lipase Requires Activation of Both Akt and Stress Kinases. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E137-47. (IF=4.31)

Protein kinase D is a Key Regulator of Cardiomyocyte Lipoprotein Lipase Secretion after Diabetes.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Kim MS, Wang F, Puthanveetil P, Kewalramani G, Hosseini-Beheshti E, Ng N, Wang Y, Kumar U, Innis S, Proud CG, Abrahani A, Rodrigues B. Protein kinase D is a Key Regulator of Cardiomyocyte Lipoprotein Lipase Secretion after Diabetes. Circ Res. 2008 Aug 1;103(3):252-60. (IF=17.37)

Cardiac Glycogen Accumulation Following Dexamethasone is Regulated by AMPK.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Puthanveetil P, Wang F, Kewalramani G, Kim MS, Hosseini-Beheshti E, Ng N, Lau W, Pulinilkunnil T, Allard MF, Abrahani A, Rodrigues B. Cardiac Glycogen Accumulation Following Dexamethasone is Regulated by AMPK. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1753-62. (IF=4.73)

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Publications

2024

Long-term safety and efficacy of transcatheter microwave and radiofrequency denervation in chronic ovine model JAHA 2024

Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches

Real world efficacy and toxicity of consolidation durvalumab following chemoradiotherapy in older Australian patients with unresectable stage III non-small cell lung cancer

2023

Expression Regulates Burn Wound Healing and Can Be Targeted to Modify Scar Characteristics.

Advanced pathophysiology mimicking lung models for accelerated drug discovery.

Leptospermum extract (QV0) suppresses malignant mesothelioma tumour growth in vitro and in vivo.

A structural analysis of the nsp9 protein from the coronavirus MERS CoV reveals a conserved RNA binding interface

Immuno Inertial microfluidics: a novel strategy for exosome subpopulation separation.

Small and large extracellular vesicles derived from pleural mesothelioma cell lines offer biomarker potential Cancers

Immunomodulatory Potential of Human Clonal Mesenchymal Stem Cells and 2 their Extracellular Vesicle Subpopulations in an Inflammatory-Mediated 3 Diabetic Rhesus Monkey Model, accepted in Life Sciences.

A novel dye-sensitised solar cell based portable sensor for chemical detection, Accepted in Sensors and Actuators B: Chemical

Engineered extracellular vesicles expressing ICAM-1: A promising targeted delivery system for T cell modifications

Lidocaine for Neuropathic Cancer Pain (LiCPain): study protocol for a mixed methods pilot study

High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma.

2022

Exploring MicroRNA and exosome involvement in malignant pleural mesothelioma drug response.

Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone (PCL) electrospun scaffold accelerates burn wound healing.

3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumour microenvironment for drug response studies.

Exploring the role of extracellular vesicles and their protein cargo in lung cancer metastasis: a review

Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations.

Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses.

Extracellular vesicles from biological fluids as potential markers in castration resistant prostate cancer.

Bacterial extracellular vesicles and their novel applications in health.

Lipidomics profiles of plasma microvesicles differ in experimental cerebral malaria, compared to malaria without neurological complications.

GUIDE: a randomised non-comparative phase II trial of biomarker-driven intermittent docetaxel versus standard-of-care docetaxel in metastatic castration-resistant prostate cancer (clinical trial protocol)

The Minimum Standard of Care for Managing Malignant Pleural Mesothelioma in Developing Nations within the Asia-Pacific Region.

3-Dimensional mesothelioma spheroids provide closer to natural pathphysiological tumour microenvironment for drug response studies.

2021

The contradictory role of androgens in cutaneous and major burn wound healing.

Extracellular vesicles as biomarkers in Malignant Pleural Mesothelioma: A review.

Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions.

Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: implications for clinical practice.

Evaluation of a Mainstream Model of Genetic Testing for Men with Prostate Cancer

The Role of E-Cadherin and microRNA on FAK Inhibitor Response in Malignant Pleural Mesothelioma (MPM)

2020

Retrospective evaluation of the use of pembrolizumab in malignant pleural mesothelioma.

The Current Understanding of Asbestos-Induced Epigenetic Changes Associated with Lung Cancer. Lung Cancer

A Potential Alternative Method in Diagnosis Compared to Fluorescnece In Situ Hybridisation

2019

Transvascular Pacing of aorticorenal ganglia provides testable procedural endpoint for renal artery denervation.

Extracellular vesicles and microvascular pathology: Decoding the active dialogue.

Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer.

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis.

Host- and microbiota-derived extracellular vesicles, immune function and disease development.

High BIN1 expression has a favourable prognosis in malignant pleural mesothelioma and is associated with tumor infiltrating lymphocytes

Patterns of care and survival of older patients with malignant pleural mesothelioma

2018

Transcatheter microwave ablation can deliver deep and circumferential perivascular nerve injury without significant arterial injury to provide effective renal denervation.

Extracellular vesicles as mediators of immunopathology in infectious diseases.

Interplay of Extracellular Vesicles and Other Players in Cerebral Malaria Pathogenesis.

Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma

2017

Role of hepatic Annexin A6 in fatty acid -induced lipid droplet formation.

Geographic and socioeconomic factors in patients with malignant pleural mesothelioma in New South Wales and their impact upon clinical outcomes

Tumour suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study. Lancet Oncology

2016

Exosomes Confer Pro-survival Signals to Alter the Phenotype of Prostate Cells in Their Surrounding Environment.

Epidermal Growth Factor in Prostate Cancer derived Exosomes.

2015